Relevance. Amyloidosis of the colon is a rare disease that occurs without clinical manifestations, and, as a rule, is an incidental finding during colonoscopy. In this regard, the authors presented a clinical case of a 68-year-old patient, whose diagnosis was established on the basis of an endoscopic picture and examination of biopsy material stained with Congo red solution under polarized light microscopy The purpose of the study was to demonstrate the clinical observation of colon amyloidosis Materials and methods. The case history of a 68-year-old patient diagnosed with amyloidosis of the colon is presented.