Manganese-Doped Mesoporous Magnetic Nanocarriers for Cancer Treatment

To achieve maximum curative effects and minimize side effects in trimodal synergistic cooperative tumor therapies, we propose a strategy of photothermal (PTT)-chemodynamic (CDT)-coordinated drug chemotherapy (DT) trimodal synergistic therapy. We designed a multifunctional manganese-doped mesoporous magnetic nanodrug carrier (NH2-MMNPs), which was equipped with pullulan oxide to form Schiff base bonds upon loading doxorubicin (DOX), thus creating an oMMNPs/DOX nanoplatform. This nanoplatform exhibits excellent controlled drug release, satisfactory photothermal conversion efficiency under NIR (808 nm) irradiation, good biodegradability, and targeted drug delivery capabilities. It also produces Fenton-like Mn2+ in response to the highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating chemodynamic therapy. The oMMNPs/DOX demonstrated remarkable killing efficacy in HeLa and MCF-7 cancer cell cultures and reached 84.1% tumor suppression in vivo. The in vitro and in vivo results confirm that this theranostic nanoplatform exhibits excellent biocompatibility and anticancer effects. Therefore, oMMNPs/DOX have potential utility as a magnetically targeted and pH/GSH/NIR triple-triggered drug carrier for synergistic PTT/CDT/DT therapy.