受体
兴奋剂
肠道菌群
去甲肾上腺素
内分泌学
生物
内科学
化学
免疫学
医学
生物化学
多巴胺
作者
Setsuko Kato,Takehiro Sato,Hiroki Fujita,Masahiro Kawatani,Yoshio Yamada
标识
DOI:10.1038/s41598-021-88612-x
摘要
There is a close relationship between the gut microbiota and metabolic disorders. In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of norepinephrine. Chemical sympathectomy blocked these events. Norepinephrine was found to pass into the intestinal lumen in vitro. c-Fos staining of the intermediolateral nucleus was identified as indirect evidence of sympathetic nervous system activation of the intestinal tract by GLP-1RA. Under normal conditions, the increase in E. coli did not affect the host. However, in mice with colitis, bacterial translocation was observed with attenuation of tight junction gene expression. This is the first study to investigate the unique underlying mechanisms related the effects of GLP-1RA on changes in the gut bacterium.
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