光热治疗
癌症研究
胰腺癌
转移
放射治疗
医学
癌症
肿瘤进展
胰腺肿瘤
内科学
化学
肿瘤科
材料科学
纳米技术
作者
Xiumin Shi,Qing Li,Chuan Zhang,Hailong Pei,Guanglin Wang,Hui Zhou,Longfei Fan,Kai Yang,Bo Jiang,Rui Wang,Ran Zhu
标识
DOI:10.1186/s12951-021-01083-0
摘要
Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need.We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. 177Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), 177Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, 177Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis.Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects.
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