The intricate roles of RCC1 in normal cells and cancer cells
细胞生物学
癌症研究
生物
癌症
癌细胞
作者
Jing Li,Hang Fai Kwok
出处
期刊:Biochemical Society Transactions [Portland Press] 日期:2022-02-22
标识
DOI:10.1042/bst20210861
摘要
RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog). RCC1 plays an essential role in the regulation of cell cycle-related activities such as nuclear envelope formation, nuclear pore complex and spindle assembly, and nucleocytoplasmic transport. Over the last decade, increasing evidence has emerged highlighting the potential relevance of RCC1 to carcinogenesis, especially cervical, lung, and breast cancer. In this review, we briefly discuss the roles of RCC1 in both normal and tumor cells based on articles published in recent years, followed by a brief overview of future perspectives in the field.