药代动力学
骨质疏松症
药理学
医学
中医药
口服
内科学
病理
替代医学
作者
Hua Yin,Yahong Wang,Ling Wang,Xue Bai,Jianhua Zhang
标识
DOI:10.1002/jssc.202100689
摘要
You-Gui-Wan is a traditional Chinese patent medicine that has been extensively used to treat kidney-yang deficiency syndrome. An high-performance liquid chromatography tandem mass spectrometry method was developed to measure contents of 12 components of You-Gui-Wan in rat plasma. Considering that pathological changes might directly affect the pharmacokinetic behavior of drugs, this method was further applied to compare pharmacokinetics between normal and osteoporotic animals. The results indicated that osteoporosis significantly altered the pharmacokinetic characteristics of the 12 components. Thus, the pharmacokinetics of You-Gui-Wan evaluated under osteoporotic conditions was much closer to clinical practice than that in normal physiological states. Thus, the optimized analytical method, along with the pharmacokinetic evaluation in the osteoporotic model may offer a more comprehensive understanding to elucidate the anti-osteoporosis mechanism of You-Gui-Wan. These findings may aid in developing a more effective treatment plan for osteoporosis.
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