P369. First-in-Human Use of Low Intensity Focused Ultrasound in Depressed Patients: Safety and Tolerability Outcomes

Low intensity focused ultrasound (LIFU) represents a potentially paradigm-shifting technology in neuropsychiatric research. This technology applies non-invasive acoustic energy to reversibly modulate cortical and subcortical structures with millimeter precision. We are currently performing first-in-human studies of LIFU in depressed and anxious patients. This study intends to measure the safety and tolerability of LIFU targeting the amygdala, a core neural region implicated in a broad range of psychopathology.