立体中心
对映选择合成
磷酰胺
硫醚
催化作用
环加成
化学
组合化学
对映体
基质(水族馆)
立体化学
有机化学
寡核苷酸
地质学
海洋学
DNA
生物化学
作者
Bin Feng,Jia‐Rong Chen,Yun‐Fang Yang,Bin Lü,Wen‐Jing Xiao
标识
DOI:10.1002/chem.201705301
摘要
Abstract In contrast to the plethora of catalytic systems that enable access to any enantiomers of the chiral products by simply choosing between a pair of enantiomeric or pseudoenantiomeric chiral catalysts, few analogously effective protocols exist for the synthesis of compounds bearing multiple stereogenic centers with full control of the absolute and relative stereochemical configurations. Here, we report the application of our previously developed modular phosphoramidite‐thioether ligands for the copper‐catalyzed diastereodivergent asymmetric 1,3‐dipolar cycloaddition of azomethine ylides and nitroalkenes. Our catalytic system enables wide substrate scope, great stereochemical control, and high reaction efficiency.
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