医学
细胞毒性T细胞
人口
T细胞
CD8型
心肌炎
心力衰竭
免疫学
自身免疫
炎症
免疫系统
启动(农业)
内科学
生物
植物
环境卫生
发芽
生物化学
体外
作者
Elvira Forte,Bryant Perkins,Amalia Sintou,Harkaran Kalkat,Angelos Papanikolaou,Catherine Jenkins,Mashael Alsubaie,Rasheda A. Chowdhury,Theodore M. Duffy,Daniel A. Skelly,Jane Branca,Mohamed Bellahcene,Michael Schneider,Siân E. Harding,Milena B. Furtado,Fu Siong Ng,Muneer G. Hasham,Nadia Rosenthal,Susanne Sattler
出处
期刊:Circulation
[Lippincott Williams & Wilkins]
日期:2020-12-10
卷期号:143 (8): 821-836
被引量:84
标识
DOI:10.1161/circulationaha.120.044581
摘要
Activation of cytotoxic CD8+ T cells by cross-priming DC contributes to exacerbation of postischemic inflammatory damage of the myocardium and corresponding decline in cardiac function. Importantly, this provides novel therapeutic targets to prevent postischemic immunopathology and heart failure.
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