焦虑
医学
冲程(发动机)
萧条(经济学)
生活质量(医疗保健)
医院焦虑抑郁量表
改良兰金量表
心房颤动
内科学
物理疗法
精神科
缺血性中风
缺血
经济
护理部
宏观经济学
工程类
机械工程
作者
Monika Sadlonova,Katrin Wasser,Jonas Nagel,Mark Weber-Krüger,Sonja Gröschel,Timo Uphaus,Jan Liman,Gerhard F. Hamann,Pawel Kermer,Klaus Gröschel,Christoph Herrmann‐Lingen,Rolf Wachter
标识
DOI:10.1016/j.jpsychores.2020.110353
摘要
Stroke can negatively impact the health-related quality of life (HRQoL). Anxiety or depression after stroke have been associated with poorer HRQoL, higher mortality and greater dependence in activities of daily living. We aimed to analyze HRQoL, anxiety and depressive symptoms in patients with and without atrial fibrillation (AF) up to 12 months post-stroke. Find-AFRANDOMISED was a prospective, randomized multicenter study, which included 398 patients ≥60 years with acute cerebral ischemia. HRQoL data were collected using the 3-level EuroQol-5D (EQ-5D-3L) and Stroke Impact Scale (SIS-16). Anxiety and depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS). The severity of stroke was measured using the modified Rankin Scale (mRS). In this study (mean age 72.7 ± 7.5 years, 40.2% females), there was a significant improvement in HRQoL using EQ-5D-3L after 3 months (β = 0.37, p < .01), 6 months (β = 0.43, p < .01) and 12 months (β = 0.44, p < .01) post-stroke compared to baseline. HADS anxiety scores after 3 months (β = −0.22, p < .01) and 12 months (β = −0.28, p < .01) were significantly reduced. Older patients reported reduced HRQoL and more depressive symptoms. Females indicated lower HRQoL and more anxiety. mRS score at baseline was an independent predictor for HRQoL. There was a significant but small effect of AF on EQ-5D-3L and on HADS anxiety. Patients showed significant improvement in HRQoL and reduced anxiety after 3 and 12 months after stroke. We could demonstrate that the severity of stroke as well as sex and age impact long-term post-stroke HRQoL. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01855035.
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