血沉
医学
类风湿性关节炎
类风湿因子
内科学
自身抗体
尤登J统计
瓜氨酸
发病机制
免疫学
胃肠病学
锡尔图因
关节炎
抗体
C反应蛋白
内分泌学
接收机工作特性
精氨酸
生物
生物化学
酶
氨基酸
NAD+激酶
作者
Xin Li,Tao Zeng,Y. W. Liu,T. Hu,J.C. Huang,Yanwen Wu,Jong-Sung Yu,Zhijian Pei,Lizhen Tan
标识
DOI:10.1080/09674845.2021.1880085
摘要
Introduction: Cell biology studies, animal models and other data suggest a role for sirtuin-1 in the pathogenesis of rheumatoid arthritis (RA). We hypothesized the clinical significance of serum sirtuin-1 in this disease.Methods: Serum was obtained from 141 RA patients, 144 non-RA patients and 88 healthy controls. Sirtuin-1, anti-mutant citrulline vimentin antibody (anti-MCV), anti-cyclic citrulline polypeptide antibody (anti-CCP), rheumatoid factor and C-reactive protein were measured by immunological methods, and erythrocyte sedimentation rate was determined by the Westergren method.Results: All markers were higher in the RA group than in the non-RA group and the healthy control group (P < 0.01). The specificity of sirtuin-1 for the diagnosis of RA was 97% (the highest among all markers), sensitivity was 71%. In ROC curve analysis, the AUCs (95% CI) of sirtuin-1, anti-CCP and anti-MCV were 0.87 (0.82-0.91), 0.91 (0.88-0.94) and 0.92 (0.89-0.95) respectively (all p < 0.01). The combination of sirtuin-1and anti-MCV gave the highest Youden index of 0.79, whilst Cox regression showed sirtuin-1 and rheumatoid factor were the strongest independent predictors of RA.Conclusions: Serum sirtuin-1 is increased in RA, and may have a place is the diagnosis of this disease when combined with other markers.
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