Abstract A micro‐scale‐based approach for the numerical analysis of cement‐based materials, subjected to low‐ and high‐cycle fatigue actions, is presented in this paper. The constitutive model is aimed at describing the evolving microstructural changes caused by cyclic loading protocols. The plastic‐damage‐based model is formulated combining the concepts of fracture‐energy theories and damage stiffness degradations, representing the key phenomena occurring in concrete under fatigue.