Effects of Rice with Different Amounts of Resistant Starch on Mice Fed a High-Fat Diet: Attenuation of Adipose Weight Gain

Increasing the amount of resistant starch (RS) in the diet may confer protective effects against chronic diseases. Rice, a good dietary source of carbohydrates, also contains RS. However, it remains unclear if RS at the amount consumed in cooked rice has a health benefit. To address the question, we examined the effects of cooked rice containing different levels of RS in a diet-induced obesity rodent model. Rice containing RS as low as 1.07% attenuated adipose weight and adipocyte size gain, induced by a moderately high-fat (HF) diet, which correlated with lower leptin levels in plasma and adipose tissue. Rice with 8.61% RS increased fecal short-chain fatty acid levels, modulated HF-diet-induced adipose triacylglycerol metabolism and inflammation-related gene expression, and increased fecal triglyceride excretion. Hence, including rice with RS level at ≥1.07% may attenuate risks associated with the consumption of a moderately HF diet.