易普利姆玛
医学
无容量
不利影响
免疫系统
免疫疗法
黑色素瘤
免疫学
自身免疫性脑炎
脑炎
癌症
内科学
癌症研究
病毒
作者
Aikaterini Gkoufa,Helen Gogas,Panagiotis Diamantopoulos,Dimitrios C. Ziogas,Mina Psichogiou
出处
期刊:Journal of Immunotherapy
[Ovid Technologies (Wolters Kluwer)]
日期:2020-06-16
卷期号:43 (7): 224-229
被引量:5
标识
DOI:10.1097/cji.0000000000000326
摘要
After the approval of immune checkpoint inhibitors for the treatment of many solid tumors, a new class of adverse events was recognized through the augmented activation of T cells, known as immune-related toxicities (immune-related adverse events). Encephalitis as an immune-mediated phenomenon is extremely rare, but potentially fatal, and questions remain with regard to its optimal management. Herein, we describe a patient with metastatic melanoma who developed autoimmune encephalitis following treatment with nivolumab plus ipilimumab and present the data concerning clinical features, diagnostic procedure, and therapeutic management of neurological immune-related adverse events. Early recognition and management, and high doses of immunosuppressive agents are the proposed essential strategies for patients’ recovery. As immune-related toxicities may represent a clinical biomarker for cancer response to immune checkpoint inhibitors, these adverse events should promptly be managed to ensure that patients will experience the benefits of cancer immunotherapy.
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