MPTP公司
多巴胺能
黑质
酪氨酸羟化酶
小胶质细胞
纹状体
单叶灰树
帕金森病
神经毒素
化学
多巴胺
神经毒性
内分泌学
内科学
神经科学
生物
凝集素
免疫学
医学
生物化学
毒性
炎症
疾病
作者
Anna Członkowska,Małgorzata Kohutnicka,Iwona Kurkowska‐Jastrzębska,Andrzej Członkowski
出处
期刊:Neurodegeneration
[Elsevier]
日期:1996-06-01
卷期号:5 (2): 137-143
被引量:262
标识
DOI:10.1006/neur.1996.0020
摘要
We studied the microglial reaction in mice using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model for Parkinson's disease (PD). Microglial cells were identified by means of the Griffonia simplicifolia lectin (GSA-I-B4). Dopaminergic neurons were marked by tyrosine hydroxylase antibodies. Microglial activation was demonstrated by an increase in cellular number and changes of morphology (increased lectin staining, larger cell bodies and thicker processes) were seen in the substantia nigra from the 1st to the 14th day and in the striatum from the 1st to the 4th day after intoxication. Depletion of dopaminergic neurons was most pronounced 7 and 14 days following the treatment. The results suggest that microglial activation may be involved in the sequence of pathological changes that lead to dopaminergic neuronal damage after MPTP intoxication.
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