对比度(视觉)
磁共振成像
镝
核磁共振
材料科学
纳米颗粒
成像体模
钆
放松(心理学)
居里温度
领域(数学)
磁场
凝聚态物理
化学
纳米技术
核医学
物理
放射科
光学
医学
数学
内科学
铁磁性
无机化学
冶金
纯数学
量子力学
作者
Gautom Kumar Das,Noah J. J. Johnson,Jordan Cramen,Barbara Błasiak,Peter Latta,Bogusław Tomanek,Frank C. J. M. van Veggel
摘要
A major limitation of the commonly used clinical MRI contrast agents (CAs) suitable at lower magnetic field strengths (<3.0 T) is their inefficiency at higher fields (>7 T), where next-generation MRI scanners are going. We present dysprosium nanoparticles (β-NaDyF4 NPs) as T2 CAs suitable at ultrahigh fields (9.4 T). These NPs effectively enhance T2 contrast at 9.4 T, which is 10-fold higher than the clinically used T2 CA (Resovist). Evaluation of the relaxivities at 3 and 9.4 T show that the T2 contrast enhances with an increase in NP size and field strength. Specifically, the transverse relaxivity (r2) values at 9.4 T were ∼64 times higher per NP (20.3 nm) and ∼6 times higher per Dy(3+) ion compared to that at 3 T, which is attributed to the Curie spin relaxation mechanism. These results and confirming phantom MR images demonstrate their effectiveness as T2 CAs in ultrahigh field MRIs.
科研通智能强力驱动
Strongly Powered by AbleSci AI