Due to frequent earthquakes in recent years, the seismic safety of large storage tank is very important. In this paper, seismic response of large liquid storage tanks is analyzed. A model for liquid storage tank is established firstly. By modality analysis, dynamic behavior of large storage tank is obtained. After the model is excitated by seismic, seismic responses are obtained. The conclusions show that, without considering liquid-solid coupling, "elephant foot" buckling phenomenon doesn’t appear. This study provides reference for seismic design and seismic performance study of large storage tank.