爪蟾
两栖动物
互补DNA
水通道蛋白2
水通道蛋白
水通道蛋白1
编码区
分子生物学
生物
克隆(编程)
细胞生物学
水道
基因
遗传学
计算机科学
程序设计语言
入口
工程类
机械工程
生态学
作者
Laurence Abrami,Matthieu Simon,Germain Rousselet,Véronique Berthonaud,Jean‐Marie Buhler,Pierre Ripoche
标识
DOI:10.1016/0005-2736(94)90155-4
摘要
A new member of the family of water channel proteins (aquaporin-CHIP) related to the major intrinsic protein (MIP) family is described. The cDNA coding for this amphibian CHIP was cloned from frog (Rana esculenta) urinary bladder, a model for the kidney collecting duct, using a RT-PCR cloning strategy. The encoded protein, designated FA-CHIP (frog aquaporin-CHIP), shows 77.4%, 42.4% and 35.6% identity with the three proteins now referred to as the aquaporins of the MIP family, i.e., human CHIP28, WCH-CD and gamma-TIP, respectively. Xenopus leavis injected with FA-CHIP cRNA exhibited a marked increase of the osmotic water permeability.
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