增强子
染色质
抄写(语言学)
转录因子
生物
发起人
细胞生物学
嘉雅宠物
基因
调节顺序
核受体
遗传学
染色质重塑
基因表达
语言学
哲学
作者
Katherine Cullen,Michael P. Kladde,Mark A. Seyfred
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1993-07-09
卷期号:261 (5118): 203-206
被引量:176
标识
DOI:10.1126/science.8327891
摘要
The regulation of transcription requires complex interactions between proteins bound to DNA sequences that are often separated by hundreds of base pairs. As demonstrated by a nuclear ligation assay, the distal enhancer and the proximal promoter regions of the rat prolactin gene were found to be juxtaposed. By acting through its receptor bound to the distal enhancer, estrogen stimulated the interaction between the distal and proximal regulatory regions two- to threefold compared to control values. Thus, the chromatin structure of the prolactin gene may facilitate the occurrence of protein-protein interactions between transcription factors bound to widely separated regulatory elements.
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