Analysis of the Monitoring Results of Blood Concentration of Carbamazepine in 189 Patients with Epilepsy

OBJECTIVE:To evaluate the clinical use of carbamazepine.METHODS:The monitoring results of blood concentration of carbamazepine in 189 patients with epilepsy after treatment with carbamazepine were analyzed retrospectively. RESULTS:As for blood concentration of carbamazepine,4 mg·L~(-1) appeared in 32 FD cases,and 20(62.5%) of the them were effective, 12 mg·L~(-1) was found in 2 FD cases,and both(100%) of the two cases were effective,and 4～12 mg·L was found in 15,5 cases,of whom,114(73.5%) were effective.When comparing the effective rate between the patients receiving carbamazepine alone and those treated with carbamazepine in combination with other antiepileptic drugs,all P 0.05, therefore,significant difference between the two groups in the total effective rate could not be considered.CONCLUSION: The blood concentration of carbamazepine showed great individual difference.Individualized dosage regimen should be made based on the monitoring on the blood concentration of carbamazepine and its clinical therapeutic effect.