亮氨酸拉链
拉链
DNA
基因
碱性螺旋-环-螺旋-亮氨酸拉链转录因子
bZIP域
DNA结合蛋白
转录因子
生物
亮氨酸
结合位点
氨基酸
遗传学
细胞生物学
算法
计算机科学
出处
期刊:PubMed
日期:1990-02-01
卷期号:1 (1): 19-26
被引量:43
摘要
The nuclear proto-oncogenes, c-fos and c-jun, are induced in response to a diverse array of extracellular stimuli. Their protein products, Fos and Jun, form a heterodimeric complex that interacts with the DNA regulatory element known as the AP-1 binding site. Protein dimerization occurs via a parallel interaction of leucine zipper domains and is required for DNA binding. In addition to the leucine zipper, DNA binding requires two clusters of basic amino acids adjacent to the leucine zipper domains of both Fos and Jun. The leucine zipper and DNA-binding regions are highly conserved among the c-fos and c-jun families of related inducible genes. Thus, multiple protein complexes can be formed that may interact with AP-1 binding sites in numerous genes to affect gene expression in response to environmental signals.
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