Migraine is a common clinical neurovascular headache.It has a high incidence of recurrent features.The severe migraines affect the normal life of patients and their families,bring huge economic burden.In this paper,we explore the mechanism of migraine,and briefly propose the preventive treatment of migraine.Migraine is closely related to psychological disorder and cognitive function.Inevitably,long-term attack of migraine damage spirit status,therefore,migraine should be the integrated state of brain and heart impairment.Hopefully,focusing on mind during the treatment of migraine could provide theoretical foundation and idea for its prophylactic therapeutic regimen.