Clinical observation of mifepristone in combination with methotrexate for the medical treatment of ectopic pregnancy

Objective To investigate the effect of mifepristone in combination with methotrexate for the medical treatment of ectopic pregnancy. Methods All patients with ectopic pregnancy for medical management were analysed retrospectively.Treatment consisted of methotrexate injected intramuscularly and 400 mg of mifepristone, administered orally,compared with a previous group who received only methotrexate alone.Results Success rate was 85% in combination group. Success rate was similar with that in methotrexate alone group.The time until Serum (3- hCG resolution in combination group was(22.64±6.77)d versus(27.22±6.11)d in methotrexate alone group( P 0.05). Conclusion The success rate of mifepristone in combination with methotrexate was similar to that of methotrexate alone. The time until Serum (3 - hCG resolution in combination group was shorter than that in methotrexate alone group.