Effect of Atorvastatin on Endothelial Function in Hypertensives Without Hyperlipemia

Objective To investigate the effect of different dose of atorvastatin on endothelium dependent vasodilatation function in hypertensives without hyperlipemia in attempt to verify the hypothesis of beyond antihyperlipimia effect of statins.Methods Fifty-five hypertensives without hyperlipemia were randomly to receive atorvastatin(10 mg/d,n=25)or(20 mg/d,n=30).Twenty-five normotensives were enrolled in control group.Serum cholesterol were determined.Flow-mediated dilation(FMD)and endothelium-independent dilatation(EID)were measured with high-resolution ultrosonography before and after 4 weeks atorvastatin.Results Compared with control group,FMD were significant decreased in hypertensives without hyperlipemia.FMD were improved after atorvastatin for 4 weeks(atorvastatin 10 mg group:7.5%±2.7% vs 11.5%±3.1%,P0.05;atorvastatin 20 mg group:7.3%±3.4% vs 14.7%±2.5%,P0.01),while no changes in EID were found.FMD was improved more greatly in atorvastatin 20 mg group than atorvastatin 10 mg group(P0.05).Conclusion Atorvastatin dose dependently improves endothelial function in hypertensives without hyperlipemia.