Therapeutic effect of total salvianolic acid on mice with pulmonary fibrosis induced by Bleomycin

Objective To study the therapeutic effects of total salvianolic acid on Bleomycin-induced pulmonary fibrosis in mice.Methods The pulmonary fibrosis model was established by intratracheal injection of Bleomycin.The lung index,pathomorphology,and level of hydroxyproline(Hyp) in lung tissue were measured to observe the effect of total salvianolic acid on pulmonary fibrosis of mice.Results Total salvianolic acid could obviously reduced alveolitis and fibrosis.The lung index was significantly decreased in total salvianolic acid group compared with that in model group,and the level of Hyp was significantly lower than that in model group(P0.05 and 0.01).Conclusion Total salvianolic acid could have therapeutic effects on Bleomycin-induced pulmonary fibrosis in mice.