戒毒(替代医学)
肝毒素
微囊藻毒素
雪卡毒素
急性毒性
碱性磷酸酶
生物化学
磷酸酶
作者
Ling-ling Fu,Xiao-yu Zhao,Lin-dan Ji,Jin Xu
出处
期刊:Toxicon
[Elsevier]
日期:2019-03-15
卷期号:160: 1-7
被引量:24
标识
DOI:10.1016/j.toxicon.2018.12.007
摘要
Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma cells, to OA induces morphological and functional modifications as well as the death of cells. As the number of reports on OA poisoning has increased, this toxin has gradually attracted the public's attention, and researchers are trying to study it. This review summarizes the current literature on the toxicity effects of OA, in addition to its detection and detoxification.
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