光学相干层析成像
光学
内窥镜
临床前影像学
背景(考古学)
光学(聚焦)
内窥镜
材料科学
体内
物理
共焦
医学
放射科
生物
生物技术
古生物学
作者
Hamid Pahlevaninezhad,Mohammadreza Khorasaninejad,Yao-Wei Huang,Zhujun Shi,Lida P. Hariri,David C. Adams,Vivien Ding,Alexander Y. Zhu,Cheng‐Wei Qiu,Federico Capasso,Melissa J. Suter
出处
期刊:Nature Photonics
[Springer Nature]
日期:2018-07-30
卷期号:12 (9): 540-547
被引量:256
标识
DOI:10.1038/s41566-018-0224-2
摘要
Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth-of-focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at sub-wavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the input field Rayleigh range, easing the trade-off between transverse resolution and depth-of-focus. We demonstrate endoscopic imaging both in resected human lung specimens and in sheep airways in vivo. The combination of the superior resolution and higher imaging depth-of-focus of the nano-optic endoscope will likely increase the clinical utility of endoscopic optical imaging.
科研通智能强力驱动
Strongly Powered by AbleSci AI