神经科学
心理学
腹侧纹状体
伏隔核
纹状体
基底神经节
计算机科学
认知心理学
前额叶皮质
情景记忆
功能磁共振成像
眶额皮质
作者
Cristian Buc Calderon,Esther De Loof,Kate Ergo,Anna Snoeck,Carsten N. Boehler,Tom Verguts
标识
DOI:10.1101/2020.01.03.893578
摘要
A growing body of behavioral evidence implicates reward prediction errors (RPEs) as a key factor in the acquisition of episodic memory. Yet, important neural predictions related to the role of RPE in declarative memory acquisition remain to be tested. Using a novel variable-choice task, we experimentally manipulated RPEs and found support for key predictions on the neural level with fMRI. Specifically, we demonstrate that trial-specific RPE responses in the ventral striatum (during learning) predict the strength of subsequent episodic memory (during recollection). Furthermore, functional connectivity between task-relevant processing areas (e.g., face-selective areas) and hippocampus, ventral tegmental area, and ventral striatum increased as a function of RPE value (during learning), suggesting a central role of these areas in episodic memory formation. Our results consolidate reinforcement learning theory and striatal RPEs as key operations subtending the formation of episodic memory.
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