化学
硝基
催化作用
甲醇
转移加氢
氢
电子转移
组合化学
分子
氢分子
硝基化合物
配体(生物化学)
有机化学
受体
钌
烷基
生物化学
作者
Vishakha Goyal,Naina Sarki,Kishore Natte,Anjan Ray
标识
DOI:10.1016/j.jics.2021.100014
摘要
We describe the selective transfer hydrogenation of aromatic nitro compounds to anilines using Pd/C as a heterogeneous catalyst with methanol as a green reductant. Nitroarenes bearing both electron-releasing and electron-deficient groups are amenable to this method and enable the synthesis of corresponding arylamines in moderate to good selectivities including the synthesis of butamben, a local anesthictic drug molecule. This new concise protocol is simple, ligand-free and does not require the supply of external molecular hydrogen.
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