产热
分解代谢
胰岛素抵抗
内分泌学
内科学
褐色脂肪组织
肥胖
运输机
糖尿病
脂肪组织
能源消耗
生物
氨基酸
化学
新陈代谢
医学
生物化学
基因
作者
Haipeng Sun,Yibin Wang
标识
DOI:10.1038/s42255-019-0112-1
摘要
Systemic accumulation of branched-chain amino acids (BCAAs) is a major metabolic hallmark and contributor to insulin resistance associated with obesity. A recent report identifies SLC25A44 as the BCAA transporter in mitochondrial membranes and shows that BCAA catabolism in brown adipose tissue significantly affects thermogenic activity, systemic BCAA clearance, energy expenditure and overall metabolic health.
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