Meta analysis of etiology and clinical features of recurrent acute pancreatitis in China in recent decade

Objective To summarize the etiology and clinical features of recurrent acute pancreatitis(RAP) in the recent 10 years in China. Methods Pubmed, Medline, EMbase, CNKI, Wan fang and VIP database were searched for relevant articles published from January 2001 to December 2016 usingPancreatitis,RecurrenceandEtiologyas term index words. Meta analysis was conducted by RevMan5.3 software. Results A total of 16 studies involving 3 980 patients (RAP n=1 231, AP n=2 749) were included. The age and sex were not correlated with AP recurrence. Biliary diseases, alcohol, inappropriate diets were associated with AP recurrence, but these were not the factors influencing RAP. Hyperlipidemia was responsible for the occurrence of pancreatitis in 17.00% of RAP and 10.20% of AP, with statistically significant difference(P=0.002). Hyperlipidemia was an important risk factor influencing AP relapse. The percentage of SAP in AP and RAP patients was 16.83% and 24.13%, respectively, and the complication rate was 11.43% and 15.13%, and the percentage of jaundice was 28.20% and 32.53%. Those in RAP were higher than those in AP, and the differences were statistically significant (all P<0.05). Conclusions Hyperlipidemia was the predominant risk factor for RAP in China, and the patients with RAP tend to progress into SAP, and have jaundice and complications. Key words: Pancreatitis; Recurrence; Hyperlipidemias; Meta-analysis