支气管肺发育不良
医学
荟萃分析
维生素D缺乏
维生素D与神经学
内科学
维生素
儿科
胎龄
怀孕
生物
遗传学
作者
Hye Won Park,Gina Lim,Yong-Mean Park,Misoo Chang,Jae Sung Son,Ran Lee
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2020-07-06
卷期号:15 (7): e0235332-e0235332
被引量:16
标识
DOI:10.1371/journal.pone.0235332
摘要
Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle–Ottawa Scale to assess the methodological components of each study, and used I2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference -1.463; 95% CI -2.900 to -0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD.
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