Variability of metabolic parameters and risk of heart failure: Can it be a marker of incident heart failure?

Heart Failure (HF) is the leading cause of death globally, despite recent declines in cardiovascular mortality, and its contemporary burden remains to be adequately addressed [ 1 Roth G.A. Johnson C.O. Abate K.H. et al. The burden of cardiovascular diseases among US states, 1990–2016. JAMA Cardiol. 2018; 3: 375-389 Crossref PubMed Scopus (2) Google Scholar , 2 Oliveira G.B.F. Avezum A. Roever L. Cardiovascular disease burden: evolving knowledge of risk factors in myocardial infarction and stroke through population-based research and perspectives in global prevention. Front Cardiovasc Med. 2015; 2: 00032 Crossref PubMed Scopus (70) Google Scholar , 3 Roever L. Biondi-Zoccai G. Chagas A.C.P. Non-HDL-C vs. LDL-C in predicting the severity of coronary atherosclerosis. Heart Lung Circ. 2016; 25: 953-954 Abstract Full Text Full Text PDF PubMed Scopus (14) Google Scholar , 4 Roever L. Resende E.S. Veloso F.C. et al. Abdominal obesity and association with atherosclerosis risk factors. Medicine (Baltimore). 2016; 95e1357 Crossref PubMed Scopus (36) Google Scholar , 5 Roever L. Resende E.S. Diniz A.L.D. et al. Ectopic adiposopathy and association with cardiovascular disease risk factors: the Uberlândia Heart Study. Int. J. Cardiol. 2015; 190: 140-142 Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar ]. Visit-to-visit variability of metabolic parameters and risk of heart failure: A nationwide population-based studyInternational Journal of CardiologyVol. 293PreviewThis study examined the effects of variability of four metabolic parameters, namely systolic blood pressure (BP), body mass index (BMI), fasting blood glucose (FBG), and total cholesterol level (TC) on the risk of HF. The effects of metabolic parameter variability on the risk of heart failure (HF) remain unclear. Full-Text PDF