细胞凋亡
体内
药理学
柚皮素
肺癌
吉非替尼
联合疗法
生物素化
化学
癌症研究
癌症
医学
生物化学
生物
表皮生长因子受体
内科学
类黄酮
生物技术
抗氧化剂
作者
Poonam Parashar,Chandra Bhushan Tripathi,Malti Arya,Jovita Kanoujia,Mahendra Singh,Abhishek Yadav,Amit Kumar,Anupam Guleria,Shubhini A. Saraf
标识
DOI:10.1080/21691401.2018.1505738
摘要
Co-therapy through biotin modified nanoparticles (NPs) of gefitinib (Gnb) and naringenin (Nar) was investigated for its therapeutic and synergistic potential against lung cancer. The biotin-conjugated polymeric NPs (bty-Nar/Gnb) were developed using oil in water emulsion technique and optimized using central composite design. The formulations were subjected to various in vitro (A549 cell lines) and in vivo evaluations in urethane-induced lung cancer. Co-administration of Gnb and Nar NPs displayed a significant reduction in tumour volume while restoring the biochemical parameters and serum metabolites to normal levels. Significant down-regulation of anti-apoptotic proteins (P-16, MMP-9 and Bcl-2) and up-regulation of pro-apoptotic proteins (caspase-9 and BAX) was displayed with co-therapy. This investigation demonstrated the superiority of co-therapy over individual therapy for improved therapeutic efficacy and is favourable for developing a safe, effective and targeted delivery for lung carcinoma therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI