丝氨酸
生物合成
甘氨酸
mTORC1型
细胞生物学
ATF4
化学
生物化学
转化生长因子
生物
氨基酸
信号转导
基因
磷酸化
下调和上调
PI3K/AKT/mTOR通路
作者
Brintha Selvarajah,Ilan Azuelos,Manuela Platé,Delphine Guillotin,Ellen Forty,Greg Contento,Hannah V. Woodcock,Matthew Redding,Adam Taylor,Gino Brunori,Pascal F. Durrenberger,Riccardo Ronzoni,Andy D. Blanchard,Paul F. Mercer,Dimitrios Anastasiou,Rachel C. Chambers
出处
期刊:Science Signaling
[American Association for the Advancement of Science]
日期:2019-05-21
卷期号:12 (582)
被引量:169
标识
DOI:10.1126/scisignal.aav3048
摘要
-mTORC1-ATF4 axis may represent a novel therapeutic strategy for interfering with myofibroblast function in fibrosis and potentially in other conditions, including cancer.
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