纤维
自愈水凝胶
多孔性
淀粉样蛋白(真菌学)
材料科学
蛋白质丝
纳米技术
气凝胶
制作
生物物理学
淀粉样纤维
化学工程
化学
淀粉样β
复合材料
高分子化学
生物
无机化学
替代医学
病理
疾病
工程类
医学
作者
Yiping Cao,Sreenath Bolisetty,Gianna Wolfisberg,Jozef Adamčík,Raffaele Mezzenga
标识
DOI:10.1073/pnas.1819640116
摘要
Significance Proteinaceous fibrils networks are ubiquitous in nature and span most domains of living matter. Among these, amyloid networks bear a twofold significance, due to their implication in the formation of amyloid plaques and tangles in vivo, but also the remarkable width of applications in which they start to emerge when synthesized in vitro. This work provides a solid strategy to improve the mechanical properties of amyloid networks by biosilicification and demonstrates how the resulting hydrogels can be used for further material design, such as in the fabrication of ultra-high porous aerogels. This contribution also advances our fundamental understanding of complex dynamic networks by introducing a general theoretical model capable of quantitatively capturing the effects of filament bundling on gel rigidity.
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