An Au-Fe 2 O 3 @mesoporous SiO 2 nanoreactor with a multiyolks/shell structure was synthesized through a multistep method. In this nanoreactor, the spindle Fe 2 O 3 and Au nanoparticles were inside the same mesoporous SiO 2 shell as the yolks but in a noncontact manner. The noncontact synergistic effect between Au nanoparticles and the Fe 2 O 3 spindle was studied with a Fenton-like reaction. The catalytic activity of the Au-Fe 2 O 3 @mesoporous SiO 2 nanoreactor to the Fenton-like reaction for the degradation of organic dyes was dramatically enhanced by the noncontact synergistic effect.