基因沉默
哮喘
粘液
粘蛋白
炎症
分泌物
化学
医学
癌症研究
体外
MUC1号
RNA干扰
呼吸系统
小干扰RNA
粘液纤毛清除率
免疫学
气道
转染
透明质酸
体内
痰
肺
支气管收缩
呼吸道
癌症
呼吸上皮
作者
Zhiqiang Zhao,Xinzhu Shan,Weixue Wang,Changdi Cao,Dian Chen,Lanhe Chu,Yan Zeng,Yunxuan Liu,Yue Yang,Yun Wu,Yanping Zhao,Junhe Chen,Z.Y. Wang,Xiaojuan Liu,Yahong Chen,Xueguang Lu,Jian Zhou,Lei Miao,Cong Luo
出处
期刊：ACS Nano
[American Chemical Society]
日期：2026-03-09
卷期号：20 (11): 9105-9121
标识
DOI：10.1021/acsnano.5c16693
摘要
-LNPs effectively alleviate airway inflammation and obstruction with a sustained preventive effect. Moreover, Formulation 1 effectively suppresses MUC5AC secretion in a Chronic Obstructive Pulmonary Disease (COPD) patient-derived organoid model. Collectively, we develop a clinically translatable, noninflammatory siRNA delivery platform with therapeutic potential for asthma and other MOLDs.
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