Coordination-driven self-assembly of antioxidative and anti-inflammatory cerium–luteolin nanoparticles for effective treatment of ocular alkali burns

. In a mouse model of alkali-induced corneal injury, topical CEL NPs markedly accelerate wound closure, reduce neovascularization, attenuate stromal edema, and decrease inflammatory cell infiltration. They outperform the individual components and match the efficacy of dexamethasone, without observable adverse effects. These results demonstrate a safe and effective nanotherapeutic strategy that combines dual redox modulation with anti-inflammatory mechanisms for treating ocular chemical injuries.