Pyrazinamide: A Frontline Drug Used for Tuberculosis. Molecular Mechanism of Action Resolved after 50 Years?

Target acquired! After 50 years of use, has the molecular mode of action finally been identified for pyrazinamide? Recently, inhibition of trans-translation in Mycobacterium tuberculosis was suggested as a novel mode of action for this important TB drug. The results of the study by Zhang et al., reported in Science, are highlighted here.