医学
精神运动学习
怀孕
人口
社会经济地位
粗大运动技能
后代
妊娠期
儿科
产科
R代
精神运动障碍
生理学
运动技能
精神科
环境卫生
认知
生物
遗传学
作者
Tsunenobu Tamura,Robert L. Goldenberg,Victoria Chapman,Kelley E. Johnston,Sharon L. Ramey,Kathleen G. Nelson
出处
期刊:Pediatrics
[American Academy of Pediatrics]
日期:2005-09-01
卷期号:116 (3): 703-708
被引量:87
标识
DOI:10.1542/peds.2004-2189
摘要
There are limited data relating folate nutritional status of mothers during pregnancy to mental and psychomotor development of their offspring. Using an existing data set from a study on the effect of prenatal zinc supplementation on child neurodevelopment, we evaluated the association between folate nutritional status of mothers during pregnancy and neurodevelopment of their children.Maternal blood folate and total homocysteine (tHcy) concentrations were measured at 19, 26, and 37 weeks of gestation. At a mean of 5.3 years of age, 355 black children with low-socioeconomic background were given 6 tests: Differential Ability Scales, Visual and Auditory Sequential Memory, Knox Cube Test, Gross Motor Scale, and Grooved Pegboard. The scores of the tests between the 2 groups of mothers with poor versus adequate folate nutritional status classified by blood folate or tHcy concentrations were compared.There were no differences in the test scores of neurodevelopment between the 2 groups.Folate nutritional status of mothers in the later half of pregnancy assessed by plasma and erythrocyte folate and plasma tHcy concentrations had no impact on neurodevelopment of their children at age 5. It is unknown whether our findings in a low-socioeconomic population can be readily extrapolated to other populations.
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