CD28
CTLA-4号机组
白细胞介素2受体
调节器
T细胞
细胞生物学
FOXP3型
生物
调节性T细胞
细胞毒性T细胞
TCIRG1公司
转基因
化学
分子生物学
体外
免疫系统
免疫学
生物化学
基因
作者
John Engelhardt,Timothy J. Sullivan,James P. Allison
出处
期刊:Journal of Immunology
[American Association of Immunologists]
日期:2006-07-15
卷期号:177 (2): 1052-1061
被引量:124
标识
DOI:10.4049/jimmunol.177.2.1052
摘要
Abstract CTLA-4 has been shown to be an important negative regulator of T cell activation. To better understand its inhibitory action, we constructed CTLA-4 transgenic mice that display constitutive cell surface expression of CTLA-4 on CD4 and CD8 T cells. In both in vivo and in vitro T cell responses, CTLA-4 overexpression inhibits T cell activation. This inhibition is dependent on B7 and CD28, suggesting that overexpressed CTLA-4 inhibits responses by competing with CD28 for B7 binding or by interfering with CD28 signaling. In addition, expression of the transgene decreases the number of CD25+Foxp3+ T cells in these mice, but does not affect their suppressive ability. Our data confirm the activity of CTLA-4 as a negative regulator of T cell activation and that its action may be by multiple mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI