Asymmetric Catalytic Reductive Coupling of 1,3‐Enynes and Aromatic Aldehydes

Abstract Nickel‐catalyzed reductive coupling reactions of 1,3‐enynes and aromatic aldehydes efficiently afford conjugated dienols in excellent regioselectivity and modest enantioselectivity when conducted in the presence of catalytic amounts of a monodentate, P ‐chiral ferrocenyl phosphine ligand. 1‐(Trimethylsilyl)‐substituted enynes are shown to be effective coupling partners in these reactions, and the dienol products thus formed readily undergo protiodesilylation under mild conditions.