化学
维蒂希反应
叠氮化物
组合化学
炔丙基
反应条件
级联反应
序列(生物学)
级联
有机化学
催化作用
色谱法
生物化学
作者
Hongbo Wei,Yun Li,Ke Xiao,Bin Cheng,Huifei Wang,Lin Hu,Hongbin Zhai
出处
期刊:Organic Letters
[American Chemical Society]
日期:2015-12-10
卷期号:17 (24): 5974-5977
被引量:64
标识
DOI:10.1021/acs.orglett.5b02903
摘要
An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.
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