Implications of bedaquiline-resistant tuberculosis

Nazir Ahmed Ismail and colleagues1 have published their groundbreaking research on the epidemiological and genetic aspects of bedaquiline resistance and the clinical outcomes in patients with rifampicin-resistant tuberculosis. Ismail and colleagues concluded that bedaquiline resistance was associated with poorer treatment outcomes. The authors also identified the Rv0678 mutation as related to bedaquiline resistance and linked with possible bedaquiline and clofazimine cross-resistance.1