变构调节
小分子
机制(生物学)
药物发现
计算生物学
酶
癌症
生物
代谢途径
癌细胞
重编程
生物信息学
生物化学
细胞
遗传学
哲学
认识论
作者
Daniel M. Kremer,Costas A. Lyssiotis
标识
DOI:10.1038/s41589-022-00997-6
摘要
Metabolic reprogramming is observed across all cancer types. Indeed, the success of many classic chemotherapies stems from their targeting of cancer metabolism. Contemporary research in this area has refined our understanding of tumor-specific metabolic mechanisms and has revealed strategies for exploiting these vulnerabilities selectively. Based on this growing understanding, new small-molecule tools and drugs have been developed to study and target tumor metabolism. Here, we highlight allosteric modulation of metabolic enzymes as an attractive mechanism of action for small molecules that target metabolic enzymes. We then discuss the mechanistic insights garnered from their application in cancer studies and highlight the achievements of this approach in targeting cancer metabolism. Finally, we discuss technological advances in drug discovery for allosteric modulators of enzyme activity.
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