Construction of heterocyclic rings from cyclopropenes

with donor-acceptor reagents, intramolecular nucleophilic addition, and the cycloaddition reactions with 1,3-dipoles are introduced. Then, the transformation of cyclopropene precursors such as alkyl 1-chloro- or 1-alkoxy-2-aroylcyclopropanecarboxylates into five-membered heteroaromatic compounds is also mentioned. In addition, a brief outlook of the opportunity and challenges in the field of bio-orthogonal reactions related to cyclopropenes is given.