This article is an attempt made by the author to discuss the various aspects of transplantation of human organ and its legal features. Human organ and tissue transplantation was started in India in 1962. Earlier, the human organ transplant was unfettered, and human organ trafficking was rampant in the society. The parliament of India first drafted The Transplantation of Human Organ Act governing the transplantation which was passed in 1994. This act has been subsequently amended in 2011, and new rules came into force in 2014. This research paper discusses the significant mechanism of the act and spotlights on what all medical practitioners involved in transplant should know about the legal aspects of transplantation.