Design of micro-fluidic bio-reactors

We address the design of optimal reactors for supporting biological cultures using the method of topology optimization. For some years this method have been used to design various optimal microfluidic devices [1, 2, 3, 4]. We apply this method to distribute optimally biologic cultures within a flow of nutrition. From this optimized distribution alone the metabolic rate in the reactor increase by close to a factor 20.