约氏疟原虫
生物
同源的
免疫
病毒学
CD8型
主要组织相容性复合体
疟疾
基因
免疫学
免疫系统
恶性疟原虫
寄生虫血症
遗传学
作者
Walter R. Weiss,Michael F. Good,Michael R. Hollingdale,L H Miller,Jay A. Berzofsky
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1989-12-15
卷期号:143 (12): 4263-4266
被引量:66
标识
DOI:10.4049/jimmunol.143.12.4263
摘要
Using a rodent malaria system, we have shown that protective immunity to the preerythrocytic stages of malaria is genetically controlled by MHC and non-MHC genes. Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals that did not develop blood stage infections. Immunity did not correlate with antisporozoite antibody levels. Two protective mechanisms exist determined by non-H-2 genes, and each mechanism is further controlled by H-2-linked Ir genes. On the BALB background only H-2d mice are protected, and protection is abolished by depleting CD8+ T cells. In contrast, on the B10 background only H-2q mice are strongly protected, and protection is not affected by CD8+ T cell depletion. If similar complex genetic regulation of immunity occurs in the human malarias, it will be a major hurdle for vaccine development.
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